MLB Picks & Predictions for May 25, 2025 – Best Bets and Player Props for Every Game

Sunday's MLB slate is packed with action across both leagues. We break down every matchup with betting analysis, game predictions, and our top player prop picks for May 25, 2025. Below are full previews for each game.

 

New York Yankees vs. Colorado Rockies

Probable Pitchers: NYY: W. Warren (3-2, 4.05) vs. COL: A. Senzatela (1-8, 6.34)

Prediction: The Yankees have a distinct pitching edge here. Expect Warren to control the strike zone while Senzatela continues to struggle. The altitude of Coors may inflate run totals, but New York’s lineup has the firepower to outslug the Rockies.

Best Bet: Yankees -1.5

Top Prop: Aaron Judge over 1.5 total bases

Cleveland Guardians vs. Detroit Tigers

Probable Pitchers: CLE: L. Allen (2-2, 3.86) vs. DET: T. Skubal (4-2, 2.87)

Prediction: This shapes up as a low-scoring duel. Skubal has been dominant at home, and Allen has kept opponents in check consistently. Runs should be at a premium in Comerica Park.

Best Bet: Under 8.5 runs

Top Prop: Tarik Skubal over 6.5 strikeouts

Baltimore Orioles vs. Boston Red Sox

Probable Pitchers: BAL: D. Kremer (3-5, 5.50) vs. BOS: W. Buehler (4-1, 4.00)

Prediction: Boston has the advantage with Buehler on the mound, especially against an Orioles lineup that’s been inconsistent. Fenway favors right-handed power, which gives a boost to the Sox.

Best Bet: Red Sox moneyline

Top Prop: Rafael Devers to hit a home run

Milwaukee Brewers vs. Pittsburgh Pirates

Probable Pitchers: MIL: L. Henderson (3-0, 1.69) vs. PIT: B. Falter (3-3, 3.50)

Prediction: Henderson’s impressive start gives Milwaukee the edge. The Pirates remain inconsistent offensively. Look for the Brewers to control this one.

Best Bet: Brewers moneyline

Top Prop: Christian Yelich over 1.5 hits + runs + RBIs

San Francisco Giants vs. Washington Nationals

Probable Pitchers: SF: R. Ray (6-0, 2.67) vs. WSH: M. Soroka (1-2, 5.95)

Prediction: Ray remains undefeated for a reason. Soroka’s struggles suggest the Giants will have the upper hand throughout.

Best Bet: Giants -1.5

Top Prop: Matt Chapman over 1.5 total bases

Chicago Cubs vs. Cincinnati Reds

Probable Pitchers: CHC: B. Brown (3-3, 5.44) vs. CIN: N. Lodolo (4-4, 3.22)

Prediction: Lodolo’s consistency at home gives the Reds the advantage. The Cubs have a more volatile bullpen that could be exposed late.

Best Bet: Reds moneyline

Top Prop: Elly De La Cruz to steal a base

Toronto Blue Jays vs. Tampa Bay Rays

Probable Pitchers: TOR: C. Bassitt (4-2, 2.83) vs. TB: R. Pepiot (2-5, 3.99)

Prediction: Bassitt is the more reliable starter. Toronto’s bats should do enough to support him, especially if Vlad Jr. gets hot.

Best Bet: Blue Jays moneyline

Top Prop: Vladimir Guerrero Jr. over 1.5 total bases

Kansas City Royals vs. Minnesota Twins

Probable Pitchers: KC: K. Bubic (5-2, 1.47) vs. MIN: B. Ober (4-1, 3.68)

Prediction: A low-scoring affair is likely. Bubic has been elite, but Ober can match him. Lean under.

Best Bet: Under 7.5 runs

Top Prop: Bobby Witt Jr. over 1.5 total bases

Seattle Mariners vs. Houston Astros

Probable Pitchers: SEA: L. Castillo (4-3, 3.20) vs. HOU: C. Gordon (0-0, 5.59)

Prediction: Castillo is the difference maker. Houston may struggle to match his dominance, giving the edge to Seattle.

Best Bet: Mariners moneyline

Top Prop: Julio Rodriguez over 1.5 hits + runs + RBIs

Texas Rangers vs. Chicago White Sox

Probable Pitchers: TEX: P. Corbin (3-3, 3.59) vs. CHW: D. Martin (2-5, 3.49)

Prediction: Rangers’ bats should edge this one out. White Sox struggle late in games.

Best Bet: Rangers moneyline

Top Prop: Corey Seager over 1.5 total bases

Arizona Diamondbacks vs. St. Louis Cardinals

Probable Pitchers: ARI: B. Pfaadt (7-3, 3.81) vs. STL: S. Gray (5-1, 4.02)

Prediction: Gray at home is a tough challenge. Still, the D-backs are hot and Pfaadt has been sharp.

Best Bet: Over 8.5 runs

Top Prop: Nolan Arenado over 1.5 total bases

Philadelphia Phillies vs. Oakland Athletics

Probable Pitchers: PHI: J. Luzardo (5-0, 1.95) vs. OAK: G. Hoglund (1-2, 5.06)

Prediction: Luzardo is lights out right now. The A’s are simply overmatched.

Best Bet: Phillies -1.5

Top Prop: Bryce Harper over 1.5 total bases

Miami Marlins vs. Los Angeles Angels

Probable Pitchers: MIA: E. Cabrera (0-1, 5.50) vs. LAA: K. Hendricks (2-5, 5.32)

Prediction: This one could go either way. Expect runs on both sides. A high-scoring affair is in the cards.

Best Bet: Over 9.5 runs

Top Prop: Mike Trout to hit a home run

San Diego Padres vs. Atlanta Braves

Probable Pitchers: SD: D. Cease (1-3, 4.50) vs. ATL: S. Schwellenbach (3-3, 3.52)

Prediction: The Braves are the more complete team right now. Cease has been shaky. Take Atlanta at home.

Best Bet: Braves moneyline

Top Prop: Ronald Acuña Jr. over 1.5 total bases

Los Angeles Dodgers vs. New York Mets

Probable Pitchers: LAD: L. Knack (2-1, 6.17) vs. NYM: K. Senga (4-3, 1.43)

Prediction: Senga should dominate a Dodgers lineup that has struggled in day games. The Mets pull off a win to close the weekend.

Best Bet: Mets moneyline

Top Prop: Pete Alonso to hit a home run