Rams vs 49ers Prediction NFL Picks for Today 9/16

Rams vs 49ers Prediction NFL Picks for Today 9/16

© Robert Hanashiro-USA TODAY Sports


Los Angeles Rams vs. San Francisco 49ers - NFL Predictions


An NFC West showdown is on the horizon as the Los Angeles Rams play host to the San Francisco 49ers. Both teams boast a 1-0 record and displayed impressive performances in their opening games. The 49ers have had the upper hand in recent head-to-head matchups, winning 8 of the last 9 encounters, including two convincing victories last season. With the Rams as 7-point home underdogs, this matchup promises intrigue. Kickoff is set for 4:05 p.m. ET on Sunday at SoFi Stadium in Inglewood, Calif.


Team Analysis

San Francisco 49ers


The San Francisco 49ers entered the season with high expectations, and they delivered a commanding performance in week one. Facing a formidable Steelers team in Pittsburgh, they dominated with a resounding 30-7 win. This victory showcased their superiority in time of possession, total yards, first downs, and turnovers.

Impressive Offense

Quarterback Brock Purdy demonstrated his prowess, going 19 for 29 for 220 yards and 2 TDs. Despite facing a fierce Steelers pass rush, he showed composure. Standout performances from Brandon Aiyuk and Christian McCaffrey were pivotal, with Aiyuk amassing 129 yards and 2 TDs, while McCaffrey rushed for 152 yards and a touchdown.

Strong Defense

The 49ers' defense was equally impressive, intercepting Kenny Pickett twice and limiting Najee Harris to just 31 rushing yards. Key injuries include tight end George Kittle and receiver Ray Ray McCloud, both listed as probable.


Los Angeles Rams


The Los Angeles Rams defied expectations in week one with a convincing 30-13 victory over the Seahawks in Seattle. This performance indicated that the Rams could be a formidable force this season, despite doubts about their prospects.

Impactful Offense

Despite missing star receiver Cooper Kupp due to a hamstring injury, the Rams' offense thrived. Rookie Puka Nacua stepped up with 10 catches for 119 yards, and Tutu Atwell was equally productive with 6 receptions for 119 yards. Quarterback Matthew Stafford, returning from an injury, delivered an impressive performance with 334 passing yards.

Solid Defense

The Rams' defense held the Seahawks to just 180 total yards, showcasing their prowess on the defensive end. While Kupp remains listed as out and Nacua is questionable, the Rams aim to continue their winning momentum.



As the San Francisco 49ers prepare to face the Los Angeles Rams, there's a compelling case for why the 49ers will secure the win and cover the -7 points spread. Their dominating performance against the Steelers demonstrated their potential as one of the NFL's top teams this season.

Despite the Rams' surprising week one victory, the 49ers have historically dominated this matchup. With key offensive weapons and a strong defense, they have the tools to maintain their winning streak against the Rams. Expect the 49ers to secure the victory and cover the spread, solidifying their status as a top NFC contender. Stay tuned for what promises to be an exhilarating NFC West showdown and follow KingPin.pro for more NFL insights, expert picks, and in-depth analysis throughout the season.


Pick: 49ers -7 -110

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