49ers vs Giants Prediction NFL Thursday Night Football 9/21

49ers vs Giants Prediction NFL Thursday Night Football 9/21

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New York Giants vs. San Francisco 49ers - NFL Predictions


Get ready for a Thursday night showdown as the New York Giants take on the San Francisco 49ers. While the Giants pulled off a remarkable comeback win in their last game, the 49ers are favored to win and cover the spread. The absence of key players, especially Saquon Barkley, poses a significant challenge for the Giants.


Team Analysis

New York Giants

Recent Performance

The New York Giants showed resilience in their previous game, rallying from a 21-point deficit to beat the Cardinals 31-28. Daniel Jones had an impressive performance, passing for 321 yards and two touchdowns, while also rushing for 59 yards and another TD. However, the Giants face an uphill battle without star running back Saquon Barkley, who is sidelined with an ankle injury.

Key Injuries

Notably, the Giants will be without several key players in this matchup, including Ben Bredeson, Azeez Ojulari, and Andrew Thomas. Saquon Barkley's absence will have a significant impact on their offense, and the Giants must find ways to compensate for his absence.


San Francisco 49ers

Strong Start

The San Francisco 49ers have had an impressive start to the season, winning both of their games. They defeated the Rams 27-20 in their last outing, showcasing their offensive prowess. Christian McCaffrey has been a standout player, scoring a touchdown in 11 straight games, including the playoffs, and accumulating 268 rushing yards in just two games.

Favorable Matchup

With the Giants missing key defensive players and Saquon Barkley, the 49ers have a favorable matchup. The Giants' defense, ranked 32nd in scoring, faces a formidable 49ers offense that has scored at least 30 points in each of their first two games. The absence of Barkley also weakens the Giants' rushing attack, which the 49ers' defense will look to exploit.



The San Francisco 49ers are in a prime position to secure their third consecutive win this season. While the New York Giants showed resilience in their comeback win, they face significant challenges with key injuries, including Saquon Barkley's absence.

The 49ers have a potent offense led by Christian McCaffrey, and facing a weakened Giants' defense, they are favored to win and cover the -9.5 points spread. The Giants will struggle to replace Barkley's production, and their defense faces a tough test against the 49ers' scoring machine.

Expect the 49ers to capitalize on their advantages and secure a convincing victory. Stay tuned for an exciting matchup on Thursday night, and follow KingPin.pro for more NFL insights, expert picks, and in-depth analysis throughout the season.


Pick: 49ers -9.5 -125

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