MLB Best Bets and Player Props for July 22, 2025

Welcome to your go-to source for the most insightful MLB betting picks and player props. Today’s slate for Tuesday, July 22, 2025, is packed with action and value. Here are the top best bets and one player prop for each game, derived from performance trends, pitching matchups, and historical data.

 

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New York Yankees @ Toronto Blue Jays

Pick: Blue Jays ML (-130)
Analysis: Max Scherzer gets the nod against a young Schlittler. Scherzer has the experience edge and the Jays have been dominant at home.
Player Prop: Vladimir Guerrero Jr. Over 1.5 Total Bases

Baltimore Orioles @ Cleveland Guardians

Pick: Guardians ML (-145)
Analysis: With Young struggling (7.52 ERA), the Guardians should jump ahead early.
Player Prop: Josh Naylor to Hit a Home Run

Detroit Tigers @ Pittsburgh Pirates

Pick: Tigers ML (-155)
Analysis: Mize has been solid and the Tigers are on a roll offensively.
Player Prop: Riley Greene Over 1.5 Hits + Runs + RBIs

San Diego Padres @ Miami Marlins

Pick: Under 8.5 Runs
Analysis: Both pitchers have shown control. This could be a low-scoring affair.
Player Prop: Luis Arraez Over 1.5 Hits

Boston Red Sox @ Philadelphia Phillies

Pick: Phillies ML (-190)
Analysis: Cristopher Sanchez has been lights out at home. Advantage Philly.
Player Prop: Bryce Harper Over 0.5 RBIs

Cincinnati Reds @ Washington Nationals

Pick: Reds ML (-135)
Analysis: Reds' bats are heating up and they get a good matchup in Lord.
Player Prop: Elly De La Cruz to Steal a Base

Los Angeles Angels @ New York Mets

Pick: Mets -1.5 (+125)
Analysis: Senga's return and dominance makes the Mets strong favorites.
Player Prop: Pete Alonso Over 1.5 Total Bases

San Francisco Giants @ Atlanta Braves

Pick: Giants ML (-110)
Analysis: Roupp is finding his groove and Braves still lack consistency.
Player Prop: Matt Olson Over 0.5 HR

Chicago White Sox @ Tampa Bay Rays

Pick: Rays -1.5 (-110)
Analysis: Rasmussen has been sharp. Burke has struggled on the road.
Player Prop: Isaac Paredes Over 1.5 Hits + RBIs

Kansas City Royals @ Chicago Cubs

Pick: Cubs ML (-265)
Analysis: Boyd is rolling. Royals' offense can’t match pace at Wrigley.
Player Prop: Cody Bellinger Over 1.5 Total Bases

Oakland Athletics @ Texas Rangers

Pick: Rangers -1.5 (-115)
Analysis: deGrom is simply overpowering against a weak A’s lineup.
Player Prop: Corey Seager Over 0.5 HR

St. Louis Cardinals @ Colorado Rockies

Pick: Over 10.5 Runs
Analysis: Coors Field alert and weak starting pitching points to runs galore.
Player Prop: Nolan Arenado Over 1.5 RBIs

Houston Astros @ Arizona Diamondbacks

Pick: Astros ML (-125)
Analysis: Valdez has been clutch in big games. D-backs starter has struggled.
Player Prop: Yordan Alvarez Over 1.5 Total Bases

Milwaukee Brewers @ Seattle Mariners

Pick: Brewers ML (+105)
Analysis: Misiorowski’s breakout continues. Look for a strong showing on the road.
Player Prop: Christian Yelich Over 1.5 Hits + Walks

Minnesota Twins @ Los Angeles Dodgers

Pick: Dodgers -1.5 (-110)
Analysis: Yamamoto at home is lethal. Twins offense hasn’t traveled well.
Player Prop: Shohei Ohtani Over 2.5 Hits + Runs + RBIs