MLB Picks & Predictions for May 24, 2025 – Best Bets and Player Props for Every Game

The Saturday, May 24, 2025 MLB slate features a full schedule of exciting matchups. From elite pitching showdowns to high-scoring hitter-friendly ballparks, we break down every game with analysis, predictions, and our favorite betting picks. Below you’ll find previews, best bets, and top player props for each contest.

 

New York Yankees vs. Colorado Rockies

Probable Pitchers: NYY: Max Fried (6-0, 1.29 ERA) vs. COL: Kyle Freeland (0-6, 5.68 ERA)

Prediction: The red-hot Fried should dominate a weak Rockies lineup. Colorado’s home advantage at Coors Field can’t offset their pitching woes. Expect the Yankees to control this one early.

Best Bet: Yankees -1.5 run line

Top Player Prop: Aaron Judge over 1.5 total bases

Baltimore Orioles vs. Boston Red Sox (Game 1)

Probable Pitchers: BAL: Zach Eflin (3-2, 5.08 ERA) vs. BOS: TBD

Prediction: The Orioles should have the upper hand in this early game, particularly if the Red Sox go with a bullpen day.

Best Bet: Orioles moneyline

Top Player Prop: Adley Rutschman over 0.5 RBIs

Kansas City Royals vs. Minnesota Twins

Probable Pitchers: KC: Michael Wacha (3-4, 2.86 ERA) vs. MIN: Zebby Matthews (0-1, 12.00 ERA)

Prediction: Wacha’s consistency and KC’s sneaky good offense give them an edge over an inexperienced Matthews.

Best Bet: Royals moneyline

Top Player Prop: Bobby Witt Jr. over 1.5 total bases

Arizona Diamondbacks vs. St. Louis Cardinals

Probable Pitchers: ARI: Merrill Kelly (5-2, 3.26 ERA) vs. STL: Matthew Liberatore (3-3, 2.92 ERA)

Prediction: Expect a tight duel, but Kelly’s veteran edge and Arizona’s deeper lineup lean this game in their favor.

Best Bet: Under 8.5 total runs

Top Player Prop: Corbin Carroll over 1.5 total bases

Milwaukee Brewers vs. Pittsburgh Pirates

Probable Pitchers: MIL: Quinn Priester (1-2, 4.66 ERA) vs. PIT: Mitch Keller (1-6, 3.88 ERA)

Prediction: Keller deserves better than his record shows. Pittsburgh’s due for some home luck.

Best Bet: Pirates moneyline

Top Player Prop: Bryan Reynolds over 0.5 home runs

San Francisco Giants vs. Washington Nationals

Probable Pitchers: SF: Kyle Harrison (0-0, 3.38 ERA) vs. WSH: Jake Irvin (3-1, 3.88 ERA)

Prediction: Washington’s solid play at home gives them a slight edge in a fairly even matchup.

Best Bet: Nationals moneyline

Top Player Prop: CJ Abrams over 1.5 total bases

Chicago Cubs vs. Cincinnati Reds

Probable Pitchers: CHC: Colin Rea (3-0, 2.38 ERA) vs. CIN: Andrew Abbott (3-0, 1.80 ERA)

Prediction: Pitching duel incoming. Abbott has been lights out, making the Reds hard to fade at home.

Best Bet: Under 7.5 runs

Top Player Prop: Elly De La Cruz over 0.5 steals

San Diego Padres vs. Atlanta Braves

Probable Pitchers: SD: Michael King (4-2, 2.59 ERA) vs. ATL: Garrett Holmes (2-3, 4.01 ERA)

Prediction: Padres pitching depth and recent form give them value as underdogs here.

Best Bet: Padres moneyline

Top Player Prop: Fernando Tatis Jr. to hit a home run

Seattle Mariners vs. Houston Astros

Probable Pitchers: SEA: Bryce Woo (5-1, 2.65 ERA) vs. HOU: Framber Valdez (3-4, 3.57 ERA)

Prediction: Pitching duel, but Houston’s lefty bats give them the edge at home.

Best Bet: Astros moneyline

Top Player Prop: Yordan Alvarez over 1.5 total bases

Texas Rangers vs. Chicago White Sox

Probable Pitchers: TEX: Jack Leiter (3-2, 4.25 ERA) vs. CHW: Jonathan Cannon (2-5, 3.76 ERA)

Prediction: Rangers should control this one from start to finish.

Best Bet: Rangers -1.5 run line

Top Player Prop: Marcus Semien over 1.5 total bases

Baltimore Orioles vs. Boston Red Sox (Game 2)

Probable Pitchers: BAL: TBD vs. BOS: Hunter Dobbins (2-1, 3.62 ERA)

Prediction: Red Sox should bounce back strong in Game 2 with Dobbins on the bump.

Best Bet: Red Sox moneyline

Top Player Prop: Rafael Devers over 1.5 total bases

Toronto Blue Jays vs. Tampa Bay Rays

Probable Pitchers: TOR: Jose Berrios (1-1, 4.19 ERA) vs. TB: Shane Baz (3-3, 5.33 ERA)

Prediction: Both pitchers are shaky — expect runs.

Best Bet: Over 9.5 total runs

Top Player Prop: Vladimir Guerrero Jr. over 1.5 total bases

Cleveland Guardians vs. Detroit Tigers

Probable Pitchers: CLE: Luis Ortiz (2-5, 4.66 ERA) vs. DET: Casey Mize (6-1, 2.53 ERA)

Prediction: Mize should dominate a struggling Cleveland lineup.

Best Bet: Tigers -1.5 run line

Top Player Prop: Riley Greene over 1.5 total bases

Los Angeles Dodgers vs. New York Mets

Probable Pitchers: LAD: Tony Gonsolin (2-0, 4.05 ERA) vs. NYM: David Peterson (2-2, 2.86 ERA)

Prediction: Great pitching duel; slight edge to Mets at home.

Best Bet: Mets moneyline

Top Player Prop: Pete Alonso to hit a home run

Philadelphia Phillies vs. Oakland Athletics

Probable Pitchers: PHI: Cristopher Sanchez (4-1, 3.10 ERA) vs. OAK: Jeffrey Springs (5-3, 3.91 ERA)

Prediction: Phillies are simply the better team all around.

Best Bet: Phillies -1.5 run line

Top Player Prop: Bryce Harper over 1.5 total bases

Miami Marlins vs. Los Angeles Angels

Probable Pitchers: MIA: Cal Quantrill (3-4, 6.37 ERA) vs. LAA: Jose Soriano (3-4, 3.57 ERA)

Prediction: The Angels’ offense gives them the upper hand in this matchup.

Best Bet: Angels moneyline

Top Player Prop: Mike Trout over 1.5 total bases