NFL Best Bets & Player Props for TNF – Seahawks vs Cardinals (Sept. 25, 2025)

 

NFL Thursday Night Football Best Bets & Player Props – Seahawks vs. Cardinals (Sept. 25, 2025)

 

 

The NFC West takes center stage on Thursday Night Football as the Seattle Seahawks (2–1) head to State Farm Stadium to face the Arizona Cardinals (2–1). Seattle enters riding a 7-game winning streak against Arizona, but oddsmakers are calling this one tight with the Seahawks listed as slight favorites.

 

 

 

 

Game Overview

 

 

• Kickoff: 5:15 PM ET
• Location: State Farm Stadium, Glendale, AZ
• Odds: Seahawks -1.5 | Cardinals +1.5 | Total: 43.5

 

 

Seattle is coming off a blowout win over the Saints (44–13), while Arizona suffered a heartbreaking one-point loss at San Francisco (16–15). Both teams sit at 2–1 and could use this divisional win to build early momentum.

 

 

 

 

Best Bets

 

 

 

1. Seahawks -1.5 (-115)

 

 

Seattle has dominated this matchup, winning seven straight against Arizona. Sam Darnold has been efficient, completing 70% of his passes with 4 TDs and 2 INTs. More importantly, Seattle’s defense has tightened, allowing just 13 points to New Orleans last week. Arizona has been scrappy under Kyler Murray, but injuries to key pieces (CB Wilson and WR Zay Jones) hurt their depth.

 

Prediction: Seattle extends the streak with a close but controlled win.

 

 

 

 

2. Under 43.5 Points (-115)

 

 

While Seattle exploded last week, this game projects differently. Arizona plays at a slower pace with Murray mixing in short throws and designed runs. Both defenses are middle-tier in yards per play allowed, but with divisional familiarity, scoring could tighten. Expect more red-zone field goals than shootout action.

 

 

 

 

Player Props

 

 

 

Sam Darnold Passing Yards – Over 228.5 (-115)

 

 

Darnold has found a rhythm with Jaxon Smith-Njigba and Cooper Kupp in the passing game. Arizona’s secondary is thin with Wilson doubtful, and if Seattle leans on play-action, Darnold should clear this number.

 

 

 

 

Kyler Murray Rushing Yards – Over 28.5 (-115)

 

 

Murray is still Arizona’s X-factor, and Seattle’s pass rush will flush him from the pocket. He’s topped 30 rushing yards in two of three games this season and will need his legs to keep drives alive.

 

 

 

 

Kenneth Walker III Anytime TD (-125)

 

 

Walker already has 3 rushing scores and remains Seattle’s go-to option inside the red zone. Arizona’s front has allowed over 4.5 yards per carry this season, making Walker a strong bet to find the end zone.

 

 

 

 

Jaxon Smith-Njigba Receiving Yards – Over 82.5 (-115)

 

 

Smith-Njigba leads Seattle in receiving yards (323) and targets. With Cooper Kupp drawing coverage, JSN should continue to see favorable matchups and clear his total.

 

 

 

 

Trey McBride Anytime TD (+210)

 

 

The Cardinals’ TE has quickly become Kyler’s most trusted option, leading the team in catches (17). Seattle has allowed TEs to do damage in the red zone, making McBride a sneaky value play.

 

 

 

 

Final Score Prediction

 

 

Seahawks 23 – Cardinals 17

Seattle’s winning streak continues, Walker punches in another TD, and Murray’s rushing keeps Arizona competitive — but not enough to break the trend.