Arizona Cardinals vs San Francisco 49ers Prediction, Pick and Preview, November 21 (11/21) NFL

Arizona Cardinals vs San Francisco 49ers Prediction, Pick and Preview, November 21 (11/21) NFL


Time 8:15 p.m. EST
49ers money line -370
49ers spread -8 (-110)
Cardinals money line +285
Cardinals spread +8 (-110)
Over / under 43.5


2022 season stats

  San Francisco 49ers Arizona Cardinals
Record 5-4 4-6
Road / home record 2-3 1-4
Points per game 22.0 23.0
Points allowed per game 18.1 25.0
O/U 3-6 5-4-1
Pass yards per game 247.5 241.0
Rush yards per game 123.0 113.5
Total yards per game 371.5 354.5
Total yards allowed per game 301.5 372.0



The Arizona Cardinals and the San Francisco 49ers will meet in Mexico City on Monday Night at the Estadio Azteca. These teams faced each other twice last season and the Cardinals won and covered the spread on both games.


San Francisco 49ers

The 49ers get here with a 5-4 record after beating the Chargers 22-16 last week in San Francisco. Garoppolo went 19 for 28 for 240 yards while San Francisco relied heavily on the ground game, rushing 41 times for 157 yards, and defense. San Francisco held the opposition scoreless in the second half for the second straight game after allowing 44 points to Kansas City in Week 8.

The Defense has been pretty tough allowin only 18 points per game, 218 pass yards and 82 rushing yards. They dominated the Chargers the last week holding them to only 16 points in the game.


Arizona Cardinals

The Cardinals get here with a 4-6 record after beating the Rams 27-17 on the road last week. McCoy passed for 238 yards in his first start of the season, James Conner rushed for two touchdowns. Cards TD Zach Ertz injured his knee on their opening drive. The three-time Pro Bowl selection eventually went to the locker room on a cart. 

Defensively, the team has struggled, allowing 261.9 passing yards, and allowing 110.5 rushing yards per game.



San Francisco are 1-7-1 ATS in their last 9 games against Arizona.

San Francisco are 3-11 SU in their last 14 games against Arizona.

The total has gone UNDER in 6 of San Francisco's last 8 games on the road.

The total has gone UNDER in 5 of San Francisco's last 6 games when playing on the road against Arizona.

The total has gone OVER in 4 of Arizona's last 5 games.

Arizona are 5-11 SU in their last 16 games.

Arizona are 1-9 SU in their last 10 games at home.



The Cardinals looked good offensively in the abscence of their leading quarterback Kyler Murray who's still questionable for this game along with Hopkins and Marquise Brown which could complicate things for the team against the 49ers. San Francisco has won 3 of their last 5 games with outstanding performance from the defense and have won by more than 8 points in 4 of their 5 wins this season and with the Cardinals injuries I think the best play is the Niners to cover. 

PICK: 49ers -8 (-110)

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