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MLB Picks April 6, 2025: Yankees vs Pirates Prediction & Best Bets

New York Yankees vs Pittsburgh Pirates – 1:35 PM ET – PNC Park (MLB.TV)
Starting Pitchers: Will Warren (NYY) vs Andrew Heaney (PIT)
Moneyline: Yankees -155, Pirates +130
Over/Under: 9.0
Game Preview:
The Yankees look to complete a three-game sweep of the Pirates on Sunday afternoon in Pittsburgh, entering the series finale at 6-2 on the season. New York has outscored Pittsburgh 19-8 over the first two games, riding dominant middle innings and a relentless offense. The Pirates, meanwhile, continue to struggle with pitching and run prevention — dropping to 2-7 overall and 1-3 at home.
New York’s offense has been firing on all cylinders. The Yankees have posted double-digit hits in four of their last five games, with Oswaldo Cabrera, Anthony Volpe, and Trent Grisham all coming up big in Saturday’s 10-4 win. Grisham crushed two home runs and plated four runs, while Volpe added three RBIs of his own. New York has now won six straight games as a road favorite and continues to dominate NL Central opponents, going 6-0 ATS in that span.
Will Warren makes the start for the Yankees after allowing two earned runs over five innings in his 2025 debut. Warren has yet to earn his first MLB win (0-3 career record, 9.11 ERA) but showed improved command in his first outing. He’ll look to pitch deeper into this one against a Pirates offense that’s scored exactly four runs in five of its first eight games but hasn’t been able to turn those into wins.
Andrew Heaney counters for Pittsburgh after a decent first start where he allowed just one earned run in five innings. Heaney has been a league-average starter for much of his career, entering Sunday with a lifetime 4.44 ERA. The lefty has allowed a lot of hard contact historically, and this Yankees lineup is stacked with right-handed hitters who thrive in this matchup.
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Best Bet: Yankees -1.5 (+105)
New York’s offense is rolling, and their bullpen has done a great job protecting leads. The Pirates have trailed after 3 innings in 7 of their last 8 home games and haven’t covered the run line in their last eight day games following a home loss. With Warren expected to pitch to contact and Heaney facing a deep Yankees lineup, this game sets up for another double-digit run output from New York. The Yankees have covered in six straight vs NL Central opponents — this is one of the top MLB best bets today.
Top Player Prop: Anthony Volpe to Score a Run (+105)
Volpe has scored in 4 of his last 5 games and continues to be one of the Yankees’ most consistent table-setters. With Heaney’s tendency to allow early traffic and the Yankees clicking offensively, Volpe offers great value in this spot. He’s batting .290 and hitting leadoff in a game projected for plenty of runs. One of the sneakier MLB player props today for plus-money value.
Yankees vs Pirates Betting Trends:
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Yankees are 9-0 SU in last 9 road games as favorites after playing the previous day
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Pirates are 0-4 SU in last 4 home games vs AL East teams with winning records
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Yankees are 6-0 RL in last 6 games as favorites vs NL Central opponents
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Pirates are 0-8 RL in last 8 day games vs AL opponents following a home loss
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Over is 7-1 in Yankees’ last 8 day games as favorites
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Over is 4-0 in the last 4 meetings between Yankees and Pirates
Yankees vs Pirates FAQ
Who is favored in Yankees vs Pirates today?
The New York Yankees are -155 road favorites over the Pittsburgh Pirates.
What time is Yankees vs Pirates on April 6, 2025?
First pitch is set for 1:35 PM ET at PNC Park in Pittsburgh, streaming on MLB.TV.
What is the Over/Under total for today’s game?
The total is set at 9.0 runs — with the Over cashing in each of the last four matchups between these teams.
Who are the starting pitchers?
Will Warren (Yankees) vs Andrew Heaney (Pirates). Warren allowed 2 ER in 5 IP in his debut, while Heaney allowed 1 ER in 5 IP.
What’s the best MLB player prop today?
Anthony Volpe to score a run (+105) offers great value in a game where the Yankees are projected to score 5+ runs.
Which side has the edge in this matchup?
The Yankees are the better team offensively, have a stronger bullpen, and have covered in six straight games vs NL Central opponents.
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