MLB Picks & Predictions for May 28, 2025 – Best Bets and Player Props

Wednesday's MLB schedule offers a full slate of action. We’ve analyzed each matchup to deliver sharp picks and top player props. Here are your betting edges for May 28, 2025.

Yankees vs. Angels

Pitching Matchup: C. Schmidt (1-2, 4.58) vs. Y. Kikuchi (1-4, 3.17)

Best Bet: Under 8.5 runs
Top Prop: Aaron Judge to hit a home run

White Sox vs. Mets

Pitching Matchup: S. Smith (1-3, 2.36) vs. G. Canning (5-1, 2.88)

Best Bet: Mets -1.5
Top Prop: Pete Alonso over 1.5 total bases

Dodgers vs. Guardians

Pitching Matchup: C. Kershaw (0-0, 7.50) vs. Undecided

Best Bet: Dodgers moneyline
Top Prop: Freddie Freeman over 0.5 RBIs

Giants vs. Tigers

Pitching Matchup: L. Roupp (3-3, 3.63) vs. J. Jobe (4-1, 4.06)

Best Bet: Tigers moneyline
Top Prop: Riley Greene over 1.5 total bases

Red Sox vs. Brewers

Pitching Matchup: B. Bello (2-1, 4.08) vs. F. Peralta (5-3, 2.55)

Best Bet: Brewers -1.5
Top Prop: Christian Yelich to steal a base

Twins vs. Rays

Pitching Matchup: P. Lopez (4-2, 2.31) vs. D. Rasmussen (3-4, 2.60)

Best Bet: Under 7.5 runs
Top Prop: Carlos Correa over 0.5 home runs

Athletics vs. Astros

Pitching Matchup: L. Severino (1-4, 4.11) vs. L. McCullers Jr. (0-1, 6.57)

Best Bet: Astros -1.5
Top Prop: Kyle Tucker over 1.5 total bases

Pirates vs. Diamondbacks

Pitching Matchup: P. Skenes (3-5, 2.36) vs. Z. Gallen (3-6, 5.25)

Best Bet: Under 8.5 runs
Top Prop: Paul Goldschmidt over 0.5 home runs

Marlins vs. Padres

Pitching Matchup: S. Alcantara (2-7, 8.04) vs. K. Hart (2-2, 6.00)

Best Bet: Padres -1.5
Top Prop: Fernando Tatis Jr. over 2.5 total bases

Cardinals vs. Orioles

Pitching Matchup: M. Mikolas (4-2, 3.51) vs. C. Povich (1-3, 4.86)

Best Bet: Over 9.5 runs
Top Prop: Nolan Arenado over 0.5 home runs

Braves vs. Phillies

Pitching Matchup: A. Smith-Shawver (3-2, 3.67) vs. Z. Wheeler (6-1, 2.42)

Best Bet: Phillies moneyline
Top Prop: Bryce Harper over 0.5 home runs

Reds vs. Royals

Pitching Matchup: H. Greene (4-2, 2.54) vs. N. Cameron (1-1, 0.93)

Best Bet: Under 8 runs
Top Prop: Bobby Witt Jr. over 0.5 RBIs

Rockies vs. Cubs

Pitching Matchup: T. Gordon (1-1, 4.38) vs. M. Boyd (4-2, 3.42)

Best Bet: Cubs -1.5
Top Prop: Cody Bellinger to hit a home run

Blue Jays vs. Rangers

Pitching Matchup: E. Lauer (1-1, 3.31) vs. T. Mahle (5-2, 1.80)

Best Bet: Rangers moneyline
Top Prop: Corey Seager over 1.5 total bases

Nationals vs. Mariners

Pitching Matchup: T. Williams (2-5, 6.39) vs. G. Kirby (0-1, 12.27)

Best Bet: Mariners -1.5
Top Prop: Julio Rodriguez to hit a home run